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. Glutamate, using the aid of NADPH, is related using the generation of glutathione, which is by far the most potent antioxidant that safeguards the malignant cell from reactive oxygen species-mediated death. Abbreviations: FASN: fatty acid synthase; HIF-1: hypoxia-inducible factor-1; GLS: glutaminase; NH4+: ammonia; SREBP: sterol regulatory element-binding protein; HSL: hormone-sensitive lipase;